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首页> 外文OA文献 >Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue.
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Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue.

机译：登革热病毒感染中T淋巴细胞的活化。登革热儿童血清中的可溶性白细胞介素2受体，可溶性CD4，可溶性CD8，白介素2和干扰素-γ水平较高。

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It has been reported that the severe complication of dengue virus infection, dengue hemorrhagic fever (DHF) is much more commonly observed during secondary dengue virus infections than primary infections. In order to elucidate the role of T lymphocytes in the pathogenesis of DHF, we attempted to determine whether T lymphocytes are activated in vivo during dengue virus infections, by examining the levels of soluble IL-2 receptor (sIL-2R), soluble CD4 (sCD4), soluble CD8 (sCD8), interleukin-2 (IL-2) and interferon-gamma (IFN gamma) in the sera of 59 patients with DHF and 41 patients with dengue fever (DF). The levels of sIL-2R, sCD4, sCD8, IL-2, and IFN gamma were significantly higher in the acute sera of patients with DHF than in the sera of healthy children (P less than 0.001 for all markers). The acute sera of patients with DF contained higher levels of sIL-2R, sCD4, IL-2, and IFN gamma than the sera of healthy children (P less than 0.001 for sIL-2R, IL-2, and IFN gamma; P less than 0.05 for sCD4), but did not have elevated levels of sCD8. The levels of sIL-2R (P less than 0.05), sCD4 (P less than 0.001), and sCD8 (P less than 0.001) were higher in DHF than in DF on days 3-4 after the onset of fever. The levels of IL-2 and IFN gamma in patients with DHF were highest 1 d before defervescence. There were no significant differences in the levels of sIL-2R, sCD4, sCD8, IL-2, and IFN gamma among grades 1, 2, and 3 of DHF. These results indicate (a) T lymphocytes are activated and produce IL-2 and IFN gamma in vivo during DHF and DF, (b) CD4+ T lymphocytes are activated in DHF and DF, and the level of activation is higher in DHF than in DF, and (c) activation of CD8+ T lymphocytes is evident in DHF, but not in DF.
机译：据报道，在继发登革热病毒感染期间，与原发感染相比，登革热病毒感染的严重并发症即登革出血热（DHF）更常见。为了阐明T淋巴细胞在DHF发病机理中的作用，我们尝试通过检查可溶性IL-2受体（sIL-2R），可溶性CD4（ sCD4），可溶性CD8（sCD8），白介素2（IL-2）和干扰素-γ（IFN gamma）在59例DHF患者和41例登革热（DF）患者的血清中。 DHF患者的急性血清中sIL-2R，sCD4，sCD8，IL-2和IFNγ的水平显着高于健康儿童的血清（所有标志物的P均小于0.001）。 DF患者的急性血清中sIL-2R，sCD4，IL-2和IFNγ的水平高于健康儿童的血清（sIL-2R，IL-2和IFNγ的P小于0.001; P较少sCD4的平均值为0.05），但sCD8的水平并未升高。发烧后第3-4天，DHF中sIL-2R（P小于0.05），sCD4（P小于0.001）和sCD8（P小于0.001）的水平高于DF。 DHF患者去铁前1 d IL-2和IFNγ水平最高。在DHF的1、2和3级之间，sIL-2R，sCD4，sCD8，IL-2和IFNγ的水平无显着差异。这些结果表明（a）DHF和DF期间T淋巴细胞被激活并在体内产生IL-2和IFNγ，（b）DHF和DF中CD4 + T淋巴细胞被激活，DHF中的激活水平高于DF中（c）在DHF中可明显激活CD8 + T淋巴细胞，而在DF中则不明显。

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